Endocrine Abstracts

Introduction: Chemerin is a pro-inflammatory adipokine, which has been shown as a mediator between obesity and metabolic syndrome (MetS). The aim of this study was to evaluate the associations of chemerin with insulin resistance and the effects of lifestyle interventions on circulating chemerin levels in Chinese obese children.Methods: A cross-sectional study was conducted among 225 obese children (101 with MetS and 124 without MetS) and 119 lean control...

Introduction: Proton pump inhibitors (PPIs) are commonly prescribed drugs. We report a case of severe hypocalcaemia secondary to omeprazole-induced hypomagnesaemia.Case report: A 85-year-old Chinese man with stage 4 chronic kidney disease was admitted to our hospital in Jun 2014 with vomiting and weakness. On admission, he was severely hypocalcaemic (adjusted calcium 1.37 mmol/l (RI: 2.15–2.58)) and hypomagnesaemic (Mg 0.1 mmol/l (RI: 0.7–1.0))...

Background: Polycystic Ovary Syndrome (PCOS) is an endocrine disorder characterized by hyperandrogenism in women, with a high incidence of insulin resistance. Decanoic acid (DA), a naturally occurring 10-carbon fatty acid, has been shown to improve insulin sensitivity and lipid profile in an in vivo model of diabetes without the induction of weight gain. However, the effects of DA on androgen production has not been explored.Aim: The objective o...

Introduction: We report a patient with hypokalaemia secondary to Cushing’s syndrome (CS) to reinforce this commonly forgotten association.Case report: A 57 years old lady with newly diagnosed hypertension, hyperlipidaemia and diabetes mellitus presented with persistent hypokalaemia for evaluation. She had tinea corporis but otherwise did not look Cushingoid. Investigations: K 2.6 (RI: 3.50–5 mmol/l), HCO3 35 (RI: 19–31 mmol/l), ...

Introduction: Primary thyroid lymphoma (PTL) is rare and constitutes 2–5% of thyroid malignancies. The risk however increases with background Hashimoto’s thyroiditis. (HT) We report a patient with HT complicated by thyroid lymphoma and did a literature review on this topic.Case presentation: A 61-years-old Chinese lady with background HT on levothyroxine presented with an enlarging goitre of 6 months duration. There was weight loss of 3–4 ...